Interações medicamentosas
Bupropion + Cefpirome
Gravidade: Moderada
Bupropion and Cefpirome: moderate interaction.
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Resumo
Cefepime-class cephalosporins such as cefpirome can cause neurotoxicity and lower the seizure threshold, particularly in renal impairment. Together with bupropion, which also lowers the seizure threshold, the risk of seizures may be increased.
O que esta interação significa em palavras simples
Bupropion and Cefpirome can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Cefpirome belongs to Anti Bacterial.
Por que acontece
Additive lowering of seizure threshold (cephalosporin GABA-A antagonism plus bupropion's proconvulsant effect).
O que fazer
Keep the bupropion dose as low as possible and adjust cefpirome dose for renal function. Monitor for myoclonus, confusion or seizures.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Bupropion
- Bupropion + Isocarboxazid Contraindicada
- Bupropion + Linezolid Contraindicada
- Bupropion + Phenelzine Contraindicada
- Bupropion + Rasagiline Contraindicada
- Bupropion + Selegiline Contraindicada
- Bupropion + Selegiline transdermal Contraindicada
Outras interações de Cefpirome
- Amikacin + Cefpirome Moderada
- Bupropion-naltrexone + Cefpirome Moderada
- Cefpirome + Dexamethasone-tobramycin Moderada
- Cefpirome + Gentamicin Moderada
- Cefpirome + Streptomycin Moderada
- Acetylsalicylic acid + Cefpirome Leve
Perguntas frequentes
Can I take Bupropion with Cefpirome?
MediHelp rates the interaction as moderate. Bupropion and Cefpirome can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefepime-class cephalosporins such as cefpirome can cause neurotoxicity and lower the seizure threshold, particularly in renal impairment. Together with bupropion, which also lowers the seizure threshold, the risk of seizures may be increased.
How serious is the interaction between Bupropion and Cefpirome?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep the bupropion dose as low as possible and adjust cefpirome dose for renal function. Monitor for myoclonus, confusion or seizures.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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