Interações medicamentosas
Amiodarone + Levofloxacin
Gravidade: Grave
Amiodarone and Levofloxacin: major interaction.
Última atualização Fontes: US FDA label
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Resumo
Both drugs prolong the QT interval, and combined use raises the risk of torsades de pointes and other ventricular arrhythmias. The risk is higher with bradycardia, hypokalemia, hypomagnesemia, structural heart disease, older age and female sex. Amiodarone's very long half-life means the risk persists for weeks after stopping.
O que esta interação significa em palavras simples
Amiodarone and Levofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Levofloxacin belongs to Anti Bacterial.
Por que acontece
Pharmacodynamic additive QT prolongation through blockade of the IKr (hERG) potassium current by both drugs.
O que fazer
Avoid the combination if possible and choose an antibiotic with less QT effect. If it must be used, obtain a baseline ECG and repeat it after starting, correct potassium and magnesium, and stop other QT-prolonging drugs.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Levofloxacin
- Dronedarone + Levofloxacin Contraindicada
- Ibutilide + Levofloxacin Contraindicada
- Levofloxacin + Thioridazine Contraindicada
- Levofloxacin + Vandetanib Contraindicada
- Levofloxacin + Ziprasidone Contraindicada
- Adagrasib + Levofloxacin Grave
Outras interações de Amiodarone
- Amiodarone + Amisulpride Contraindicada
- Amiodarone + Arsenic trioxide Contraindicada
- Amiodarone + Dofetilide Contraindicada
- Amiodarone + Dronedarone Contraindicada
- Amiodarone + Droperidol Contraindicada
- Amiodarone + Eliglustat Contraindicada
Perguntas frequentes
Can I take Amiodarone with Levofloxacin?
MediHelp rates the interaction as major. Amiodarone and Levofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, and combined use raises the risk of torsades de pointes and other ventricular arrhythmias. The risk is higher with bradycardia, hypokalemia, hypomagnesemia, structural heart disease, older age and female sex. Amiodarone's very long half-life means the risk persists for weeks after stopping.
How serious is the interaction between Amiodarone and Levofloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and choose an antibiotic with less QT effect. If it must be used, obtain a baseline ECG and repeat it after starting, correct potassium and magnesium, and stop other QT-prolonging drugs.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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