Interações medicamentosas
Levofloxacin + Ziprasidone
Gravidade: Contraindicada
Levofloxacin and Ziprasidone: contraindicated interaction.
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Resumo
Ziprasidone is known to prolong the QT interval, and its labeling advises against combination with other QT-prolonging drugs. Adding levofloxacin increases the risk of torsades de pointes and sudden cardiac death.
O que esta interação significa em palavras simples
Levofloxacin and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levofloxacin belongs to Anti Bacterial; Ziprasidone belongs to Central Nervous System.
Por que acontece
Additive blockade of cardiac potassium channels delaying ventricular repolarization.
O que fazer
Avoid the combination and use a non-QT-prolonging antibiotic. If a fluoroquinolone is essential, consider an alternative antipsychotic or specialist advice with ECG monitoring.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Levofloxacin
- Dronedarone + Levofloxacin Contraindicada
- Ibutilide + Levofloxacin Contraindicada
- Levofloxacin + Thioridazine Contraindicada
- Levofloxacin + Vandetanib Contraindicada
- Adagrasib + Levofloxacin Grave
- Amiodarone + Levofloxacin Grave
Outras interações de Ziprasidone
- Amiodarone + Ziprasidone Contraindicada
- Amitriptyline + Ziprasidone Contraindicada
- Arsenic trioxide + Ziprasidone Contraindicada
- Bedaquiline + Ziprasidone Contraindicada
- Chloroquine + Ziprasidone Contraindicada
- Citalopram + Ziprasidone Contraindicada
Perguntas frequentes
Can I take Levofloxacin with Ziprasidone?
MediHelp rates the interaction as contraindicated. Levofloxacin and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ziprasidone is known to prolong the QT interval, and its labeling advises against combination with other QT-prolonging drugs. Adding levofloxacin increases the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Levofloxacin and Ziprasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-QT-prolonging antibiotic. If a fluoroquinolone is essential, consider an alternative antipsychotic or specialist advice with ECG monitoring.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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