Interações medicamentosas
Amiodarone + Orlistat
Gravidade: Moderada
Amiodarone and Orlistat: moderate interaction.
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Resumo
Orlistat reduces dietary fat absorption and has been reported to lower absorption of the highly lipophilic amiodarone and its metabolite. Reduced levels could lead to loss of arrhythmia control.
O que esta interação significa em palavras simples
Amiodarone and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Orlistat belongs to Miscellaneous.
Por que acontece
Reduced intestinal absorption of lipophilic amiodarone due to lipase inhibition and reduced fat availability.
O que fazer
Monitor for recurrent arrhythmia and consider checking amiodarone levels; adjust the dose if needed. Avoid starting orlistat without review if rhythm control is tenuous.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Amiodarone
- Amiodarone + Amisulpride Contraindicada
- Amiodarone + Arsenic trioxide Contraindicada
- Amiodarone + Dofetilide Contraindicada
- Amiodarone + Dronedarone Contraindicada
- Amiodarone + Droperidol Contraindicada
- Amiodarone + Eliglustat Contraindicada
Outras interações de Orlistat
- Cyclosporine + Orlistat Grave
- Cyclosporin + Orlistat Grave
- Orlistat + Triheptanoin Grave
- Beta carotene + Orlistat Moderada
- Carbamazepine + Orlistat Moderada
- Cholecalciferol + Orlistat Moderada
Perguntas frequentes
Can I take Amiodarone with Orlistat?
MediHelp rates the interaction as moderate. Amiodarone and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orlistat reduces dietary fat absorption and has been reported to lower absorption of the highly lipophilic amiodarone and its metabolite. Reduced levels could lead to loss of arrhythmia control.
How serious is the interaction between Amiodarone and Orlistat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for recurrent arrhythmia and consider checking amiodarone levels; adjust the dose if needed. Avoid starting orlistat without review if rhythm control is tenuous.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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