Interações medicamentosas
Cyclosporin + Orlistat
Gravidade: Grave
Cyclosporin and Orlistat: major interaction.
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Resumo
Orlistat can lower cyclosporine absorption and cause subtherapeutic levels, with reported risk of transplant rejection. The effect is unpredictable between patients.
O que esta interação significa em palavras simples
Cyclosporin and Orlistat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Orlistat belongs to Miscellaneous.
Por que acontece
Orlistat reduces gastrointestinal fat absorption, impairing absorption of lipophilic cyclosporine.
O que fazer
Avoid coadministration if possible. If used, monitor cyclosporine trough concentrations closely and adjust dose, and give cyclosporine at least 3 hours apart from orlistat.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicada
- Aliskiren + Cyclosporin Contraindicada
- Bcg vaccine live + Cyclosporin Contraindicada
- Bosentan + Cyclosporin Contraindicada
- Cidofovir + Cyclosporin Contraindicada
- Cyclosporin + Dengue vaccine Contraindicada
Outras interações de Orlistat
- Cyclosporine + Orlistat Grave
- Orlistat + Triheptanoin Grave
- Amiodarone + Orlistat Moderada
- Beta carotene + Orlistat Moderada
- Carbamazepine + Orlistat Moderada
- Cholecalciferol + Orlistat Moderada
Perguntas frequentes
Can I take Cyclosporin with Orlistat?
MediHelp rates the interaction as major. Cyclosporin and Orlistat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Orlistat can lower cyclosporine absorption and cause subtherapeutic levels, with reported risk of transplant rejection. The effect is unpredictable between patients.
How serious is the interaction between Cyclosporin and Orlistat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration if possible. If used, monitor cyclosporine trough concentrations closely and adjust dose, and give cyclosporine at least 3 hours apart from orlistat.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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