Interações medicamentosas
Amiodarone + Torsemide
Gravidade: Grave
Amiodarone and Torsemide: major interaction.
Última atualização Fontes: US FDA label
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Resumo
Torsemide can cause hypokalemia and hypomagnesemia, which increase the risk of QT prolongation and torsades de pointes in patients taking amiodarone. Amiodarone prolongs repolarization, so electrolyte loss lowers the threshold for arrhythmia. The risk is highest with high diuretic doses, renal dysfunction, bradycardia, structural heart disease, female sex and other QT-prolonging drugs.
O que esta interação significa em palavras simples
Amiodarone and Torsemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Torsemide belongs to Cardiovascular.
Por que acontece
Additive pharmacodynamic effect: loop diuretic-induced potassium and magnesium depletion potentiates the QT-prolonging effect of amiodarone.
O que fazer
Check serum potassium and magnesium before starting and periodically during co-therapy, especially after dose changes or intercurrent illness with vomiting or diarrhea. Replete deficits promptly and keep potassium in the high-normal range (about 4.0 mmol/L or above) and magnesium in the normal range.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Amiodarone
- Amiodarone + Amisulpride Contraindicada
- Amiodarone + Arsenic trioxide Contraindicada
- Amiodarone + Dofetilide Contraindicada
- Amiodarone + Dronedarone Contraindicada
- Amiodarone + Droperidol Contraindicada
- Amiodarone + Eliglustat Contraindicada
Outras interações de Torsemide
Perguntas frequentes
Can I take Amiodarone with Torsemide?
MediHelp rates the interaction as major. Amiodarone and Torsemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Torsemide can cause hypokalemia and hypomagnesemia, which increase the risk of QT prolongation and torsades de pointes in patients taking amiodarone. Amiodarone prolongs repolarization, so electrolyte loss lowers the threshold for arrhythmia. The risk is highest with high diuretic doses, renal dysfunction, bradycardia, structural heart disease, female sex and other QT-prolonging drugs.
How serious is the interaction between Amiodarone and Torsemide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium before starting and periodically during co-therapy, especially after dose changes or intercurrent illness with vomiting or diarrhea. Replete deficits promptly and keep potassium in the high-normal range (about 4.0 mmol/L or above) and magnesium in the normal range.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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