Interações medicamentosas
Digoxin + Torsemide
Gravidade: Grave
Digoxin and Torsemide: major interaction.
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Loop diuretics can cause hypokalemia and hypomagnesemia, which sensitise the myocardium to digoxin and increase the risk of toxicity and ventricular arrhythmias. The interaction is well documented and clinically important, especially in older patients and those with renal impairment. Digoxin concentrations themselves are not usually changed.
O que esta interação significa em palavras simples
Digoxin and Torsemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Digoxin belongs to Cardiovascular; Torsemide belongs to Cardiovascular.
Por que acontece
Pharmacodynamic: diuretic-induced potassium and magnesium depletion increases digoxin binding to Na+/K+-ATPase and enhances its arrhythmogenic effects.
O que fazer
Monitor serum potassium and magnesium regularly, keeping potassium in the normal to high-normal range. Supplement electrolytes or add a potassium-sparing agent if needed.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Torsemide
Outras interações de Digoxin
- Digoxin + Lily of the valley Contraindicada
- Digoxin + Squill Contraindicada
- Adagrasib + Digoxin Grave
- Amiodarone + Digoxin Grave
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Grave
- Amphotericin b deoxycholate + Digoxin Grave
Perguntas frequentes
Can I take Digoxin with Torsemide?
MediHelp rates the interaction as major. Digoxin and Torsemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Loop diuretics can cause hypokalemia and hypomagnesemia, which sensitise the myocardium to digoxin and increase the risk of toxicity and ventricular arrhythmias. The interaction is well documented and clinically important, especially in older patients and those with renal impairment. Digoxin concentrations themselves are not usually changed.
How serious is the interaction between Digoxin and Torsemide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly, keeping potassium in the normal to high-normal range. Supplement electrolytes or add a potassium-sparing agent if needed.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
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