Interações medicamentosas
Dexamethasone-tobramycin + Torsemide
Gravidade: Grave
Dexamethasone-tobramycin and Torsemide: major interaction.
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Loop diuretics combined with systemic aminoglycosides increase the risk of ototoxicity and nephrotoxicity, especially with volume depletion. This is relevant mainly with systemic tobramycin.
O que esta interação significa em palavras simples
Dexamethasone-tobramycin and Torsemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexamethasone-tobramycin belongs to Anti Bacterial; Torsemide belongs to Cardiovascular.
Por que acontece
Additive ototoxic and nephrotoxic effects, with diuretic-induced volume depletion raising aminoglycoside exposure in the kidney and inner ear.
O que fazer
Monitor renal function, tobramycin levels and hearing, keep the patient well hydrated, and avoid the combination if alternatives exist.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Dexamethasone-tobramycin
Outras interações de Torsemide
- Amikacin + Torsemide Grave
- Amiodarone + Torsemide Grave
- Carbenoxolone + Torsemide Grave
- Chlorthalidone + Torsemide Grave
- Digoxin + Torsemide Grave
- Ethacrynic acid + Torsemide Grave
Perguntas frequentes
Can I take Dexamethasone-tobramycin with Torsemide?
MediHelp rates the interaction as major. Dexamethasone-tobramycin and Torsemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Loop diuretics combined with systemic aminoglycosides increase the risk of ototoxicity and nephrotoxicity, especially with volume depletion. This is relevant mainly with systemic tobramycin.
How serious is the interaction between Dexamethasone-tobramycin and Torsemide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, tobramycin levels and hearing, keep the patient well hydrated, and avoid the combination if alternatives exist.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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