Interações medicamentosas
Arsenic trioxide + Fluphenazine
Gravidade: Contraindicada
Arsenic trioxide and Fluphenazine: contraindicated interaction.
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Resumo
Arsenic trioxide causes marked QT prolongation and torsades de pointes, and fluphenazine adds further QT risk. Labeling advises avoiding other QT-prolonging drugs.
O que esta interação significa em palavras simples
Arsenic trioxide and Fluphenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Arsenic trioxide belongs to Oncology; Fluphenazine belongs to Central Nervous System.
Por que acontece
Additive pharmacodynamic QT prolongation.
O que fazer
Avoid concurrent use and choose a non-QT-prolonging antipsychotic. Keep potassium and magnesium normal and monitor ECG throughout arsenic therapy.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Fluphenazine
- Dofetilide + Fluphenazine Contraindicada
- Fluphenazine + Ibutilide Contraindicada
- Fluphenazine + Pimozide Contraindicada
- Adagrasib + Fluphenazine Grave
- Alfentanil + Fluphenazine Grave
- Amiodarone + Fluphenazine Grave
Outras interações de Arsenic trioxide
- Amiodarone + Arsenic trioxide Contraindicada
- Amisulpride + Arsenic trioxide Contraindicada
- Arsenic trioxide + Clomipramine Contraindicada
- Arsenic trioxide + Dronedarone Contraindicada
- Arsenic trioxide + Gemifloxacin Contraindicada
- Arsenic trioxide + Hydroxychloroquine Contraindicada
Perguntas frequentes
Can I take Arsenic trioxide with Fluphenazine?
MediHelp rates the interaction as contraindicated. Arsenic trioxide and Fluphenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Arsenic trioxide causes marked QT prolongation and torsades de pointes, and fluphenazine adds further QT risk. Labeling advises avoiding other QT-prolonging drugs.
How serious is the interaction between Arsenic trioxide and Fluphenazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a non-QT-prolonging antipsychotic. Keep potassium and magnesium normal and monitor ECG throughout arsenic therapy.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Fluphenazine page.
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