Interações medicamentosas
Amitriptyline + Cocaine
Gravidade: Grave
Amitriptyline and Cocaine: major interaction.
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Resumo
Cocaine blocks reuptake of norepinephrine, dopamine and serotonin, and tricyclics also block norepinephrine and serotonin reuptake. Combined use can cause exaggerated sympathomimetic effects, arrhythmias, hypertension and seizures. With topical cocaine, systemic absorption is usually small, but the effect can be significant with mucosal application at high doses or in abuse.
O que esta interação significa em palavras simples
Amitriptyline and Cocaine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Cocaine belongs to Central Nervous System.
Por que acontece
Additive monoamine reuptake inhibition with potentiated adrenergic effects and additive proarrhythmic sodium channel blockade.
O que fazer
Avoid cocaine, including recreational use, in patients taking amitriptyline. For medical topical use, use the lowest dose and monitor blood pressure, heart rhythm and ECG.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicada
- Amitriptyline + Methylene blue Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amitriptyline + Pimozide Contraindicada
- Amitriptyline + Procarbazine Contraindicada
- Amitriptyline + Safinamide Contraindicada
Outras interações de Cocaine
- Cocaine + Isocarboxazid Contraindicada
- Cocaine + Phenelzine Contraindicada
- Cocaine + Procarbazine Contraindicada
- Bisoprolol + Cocaine Grave
- Citalopram + Cocaine Grave
- Clomipramine + Cocaine Grave
Perguntas frequentes
Can I take Amitriptyline with Cocaine?
MediHelp rates the interaction as major. Amitriptyline and Cocaine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cocaine blocks reuptake of norepinephrine, dopamine and serotonin, and tricyclics also block norepinephrine and serotonin reuptake. Combined use can cause exaggerated sympathomimetic effects, arrhythmias, hypertension and seizures. With topical cocaine, systemic absorption is usually small, but the effect can be significant with mucosal application at high doses or in abuse.
How serious is the interaction between Amitriptyline and Cocaine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid cocaine, including recreational use, in patients taking amitriptyline. For medical topical use, use the lowest dose and monitor blood pressure, heart rhythm and ECG.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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