Interações medicamentosas
Cocaine + Isocarboxazid
Gravidade: Contraindicada
Cocaine and Isocarboxazid: contraindicated interaction.
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Resumo
Cocaine blocks reuptake of catecholamines and serotonin, and with an MAOI it may cause severe hypertension, arrhythmias or serotonin toxicity. Topical medical use gives lower exposure but still carries risk.
O que esta interação significa em palavras simples
Cocaine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cocaine belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.
Por que acontece
Monoamine reuptake inhibition combined with inhibited monoamine metabolism increases synaptic catecholamines and serotonin.
O que fazer
Avoid cocaine in patients on MAOIs, including topical anesthetic use; choose a different local anesthetic.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicada
- Amitriptyline + Isocarboxazid Contraindicada
- Amobarbital + Isocarboxazid Contraindicada
- Amoxapine + Isocarboxazid Contraindicada
- Apraclonidine + Isocarboxazid Contraindicada
- Atomoxetine + Isocarboxazid Contraindicada
Outras interações de Cocaine
- Cocaine + Phenelzine Contraindicada
- Cocaine + Procarbazine Contraindicada
- Amitriptyline + Cocaine Grave
- Bisoprolol + Cocaine Grave
- Citalopram + Cocaine Grave
- Clomipramine + Cocaine Grave
Perguntas frequentes
Can I take Cocaine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Cocaine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cocaine blocks reuptake of catecholamines and serotonin, and with an MAOI it may cause severe hypertension, arrhythmias or serotonin toxicity. Topical medical use gives lower exposure but still carries risk.
How serious is the interaction between Cocaine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid cocaine in patients on MAOIs, including topical anesthetic use; choose a different local anesthetic.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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