Interações medicamentosas
Clomipramine + Cocaine
Gravidade: Grave
Clomipramine and Cocaine: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Cocaine blocks reuptake of norepinephrine, dopamine and serotonin, and clomipramine has similar actions on serotonin and norepinephrine. The combination can increase sympathomimetic and serotonergic effects, including hypertension, arrhythmias and serotonin toxicity. Topical use at a clinical dose has lower systemic exposure, but significant absorption can occur from mucosal use.
O que esta interação significa em palavras simples
Clomipramine and Cocaine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomipramine belongs to Central Nervous System; Cocaine belongs to Central Nervous System.
Por que acontece
Additive monoamine reuptake inhibition, with potentiated adrenergic effects and arrhythmia risk.
O que fazer
Avoid cocaine, including recreational use, in patients taking clomipramine. If topical cocaine is required, use the minimum dose and monitor blood pressure and ECG.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Clomipramine e Cocaine, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Outras interações de Clomipramine
- Arsenic trioxide + Clomipramine Contraindicada
- Clomipramine + Dofetilide Contraindicada
- Clomipramine + Droperidol Contraindicada
- Clomipramine + Isocarboxazid Contraindicada
- Clomipramine + Methylene blue Contraindicada
- Clomipramine + Pentamidine Contraindicada
Outras interações de Cocaine
- Cocaine + Isocarboxazid Contraindicada
- Cocaine + Phenelzine Contraindicada
- Cocaine + Procarbazine Contraindicada
- Amitriptyline + Cocaine Grave
- Bisoprolol + Cocaine Grave
- Citalopram + Cocaine Grave
Perguntas frequentes
Can I take Clomipramine with Cocaine?
MediHelp rates the interaction as major. Clomipramine and Cocaine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cocaine blocks reuptake of norepinephrine, dopamine and serotonin, and clomipramine has similar actions on serotonin and norepinephrine. The combination can increase sympathomimetic and serotonergic effects, including hypertension, arrhythmias and serotonin toxicity. Topical use at a clinical dose has lower systemic exposure, but significant absorption can occur from mucosal use.
How serious is the interaction between Clomipramine and Cocaine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid cocaine, including recreational use, in patients taking clomipramine. If topical cocaine is required, use the minimum dose and monitor blood pressure and ECG.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
