Interações medicamentosas
Amlodipine-hydrochlorothiazide-valsartan + Calcifediol
Gravidade: Moderada
Amlodipine-hydrochlorothiazide-valsartan and Calcifediol: moderate interaction.
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Resumo
Hydrochlorothiazide reduces urinary calcium excretion, and calcifediol increases intestinal calcium absorption. Used together they can raise serum calcium and cause hypercalcemia, particularly with high vitamin D doses or reduced renal function.
O que esta interação significa em palavras simples
Amlodipine-hydrochlorothiazide-valsartan and Calcifediol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Calcifediol belongs to Musculoskeletal.
Por que acontece
Thiazide-induced renal calcium retention adds to vitamin D-mediated increase in calcium absorption.
O que fazer
Check serum calcium (and renal function) at baseline and periodically during combined use. Reduce the vitamin D dose or review the thiazide if hypercalcemia develops.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicada
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicada
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicada
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Grave
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Grave
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Grave
Outras interações de Calcifediol
Perguntas frequentes
Can I take Amlodipine-hydrochlorothiazide-valsartan with Calcifediol?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Calcifediol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide reduces urinary calcium excretion, and calcifediol increases intestinal calcium absorption. Used together they can raise serum calcium and cause hypercalcemia, particularly with high vitamin D doses or reduced renal function.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Calcifediol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum calcium (and renal function) at baseline and periodically during combined use. Reduce the vitamin D dose or review the thiazide if hypercalcemia develops.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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