Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Calcifediol
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Calcifediol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide reduces urinary calcium excretion, and calcifediol increases intestinal calcium absorption. Used together they can raise serum calcium and cause hypercalcemia, particularly with high vitamin D doses or reduced renal function.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Calcifediol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Calcifediol belongs to Musculoskeletal.
Why it happens
Thiazide-induced renal calcium retention adds to vitamin D-mediated increase in calcium absorption.
What to do
Check serum calcium (and renal function) at baseline and periodically during combined use. Reduce the vitamin D dose or review the thiazide if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Calcifediol
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Calcifediol?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Calcifediol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide reduces urinary calcium excretion, and calcifediol increases intestinal calcium absorption. Used together they can raise serum calcium and cause hypercalcemia, particularly with high vitamin D doses or reduced renal function.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Calcifediol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum calcium (and renal function) at baseline and periodically during combined use. Reduce the vitamin D dose or review the thiazide if hypercalcemia develops.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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