Interações medicamentosas
Calcifediol + Captopril-hydrochlorothiazide
Gravidade: Moderada
Calcifediol and Captopril-hydrochlorothiazide: moderate interaction.
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Resumo
Thiazide diuretics reduce urinary calcium excretion, and calcifediol increases calcium absorption from the gut. Together they can produce hypercalcemia, which may cause nausea, confusion, arrhythmias and kidney problems.
O que esta interação significa em palavras simples
Calcifediol and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcifediol belongs to Musculoskeletal; Captopril-hydrochlorothiazide belongs to Cardiovascular.
Por que acontece
Hydrochlorothiazide enhances renal calcium reabsorption while calcifediol (a vitamin D metabolite) increases intestinal calcium absorption, producing additive rises in serum calcium.
O que fazer
Measure serum calcium at baseline and periodically during combined therapy, especially in patients with renal impairment. Reduce the calcifediol dose or stop the thiazide if hypercalcemia develops.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicada
- Captopril-hydrochlorothiazide + Dofetilide Contraindicada
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicada
- Aceclofenac + Captopril-hydrochlorothiazide Grave
- Aldesleukin + Captopril-hydrochlorothiazide Grave
- Amifostine + Captopril-hydrochlorothiazide Grave
Outras interações de Calcifediol
- Amlodipine-hydrochlorothiazide-valsartan + Calcifediol Moderada
- Amlodipine-olmesartan-hydrochlorothiazide + Calcifediol Moderada
- Amobarbital + Calcifediol Moderada
- Atenolol-chlorthalidone + Calcifediol Moderada
- Azilsartan-chlorthalidone + Calcifediol Moderada
- Calcifediol + Candesartan-hydrochlorothiazide Moderada
Perguntas frequentes
Can I take Calcifediol with Captopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Calcifediol and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics reduce urinary calcium excretion, and calcifediol increases calcium absorption from the gut. Together they can produce hypercalcemia, which may cause nausea, confusion, arrhythmias and kidney problems.
How serious is the interaction between Calcifediol and Captopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum calcium at baseline and periodically during combined therapy, especially in patients with renal impairment. Reduce the calcifediol dose or stop the thiazide if hypercalcemia develops.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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