Interações medicamentosas
Amlodipine-hydrochlorothiazide-valsartan + Diclofenac
Gravidade: Grave
Amlodipine-hydrochlorothiazide-valsartan and Diclofenac: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Diclofenac can reduce the antihypertensive efficacy of valsartan and hydrochlorothiazide. The combination of an NSAID, ARB and diuretic is associated with acute kidney injury, particularly in elderly or volume-depleted patients, and may also cause hyperkalemia.
O que esta interação significa em palavras simples
Amlodipine-hydrochlorothiazide-valsartan and Diclofenac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Diclofenac belongs to Musculoskeletal.
Por que acontece
NSAID inhibition of renal prostaglandins reduces afferent arteriolar dilation and promotes salt retention, while ARB and diuretic reduce glomerular perfusion pressure and volume.
O que fazer
Avoid regular NSAID use where possible and prefer paracetamol or topical options. If needed, use the lowest dose briefly, maintain hydration and monitor blood pressure, creatinine and potassium.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicada
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicada
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicada
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Grave
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Grave
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Grave
Outras interações de Diclofenac
- Diclofenac + Ketorolac Contraindicada
- Diclofenac + Ketorolac intranasal Contraindicada
- Aceclofenac + Diclofenac Grave
- Acemetacin + Diclofenac Grave
- Alteplase + Diclofenac Grave
- Amiloride + Diclofenac Grave
Perguntas frequentes
Can I take Amlodipine-hydrochlorothiazide-valsartan with Diclofenac?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Diclofenac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diclofenac can reduce the antihypertensive efficacy of valsartan and hydrochlorothiazide. The combination of an NSAID, ARB and diuretic is associated with acute kidney injury, particularly in elderly or volume-depleted patients, and may also cause hyperkalemia.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Diclofenac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible and prefer paracetamol or topical options. If needed, use the lowest dose briefly, maintain hydration and monitor blood pressure, creatinine and potassium.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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