Interações medicamentosas
Amoxicillin-clavulanic acid + Chloramphenicol
Gravidade: Moderada
Amoxicillin-clavulanic acid and Chloramphenicol: moderate interaction.
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Resumo
Chloramphenicol is bacteriostatic and may reduce the bactericidal effect of amoxicillin in vitro. The clinical relevance is uncertain but could matter in severe infections.
O que esta interação significa em palavras simples
Amoxicillin-clavulanic acid and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amoxicillin-clavulanic acid belongs to Anti Bacterial; Chloramphenicol belongs to Anti Bacterial.
Por que acontece
Pharmacodynamic antagonism, as inhibition of bacterial protein synthesis may reduce cell-wall-dependent killing by the beta-lactam.
O que fazer
Avoid combining them in serious infections requiring bactericidal therapy and use a single appropriate agent where possible. If both are used, monitor clinical response.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Amoxicillin-clavulanic acid
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- Amoxicillin-clavulanic acid + Pexidartinib Grave
- Amoxicillin-clavulanic acid + Pretomanid Grave
- Allopurinol + Amoxicillin-clavulanic acid Moderada
- Amoxicillin-clavulanic acid + Bcg vaccine live Moderada
- Amoxicillin-clavulanic acid + Cholera vaccine Moderada
Outras interações de Chloramphenicol
Perguntas frequentes
Can I take Amoxicillin-clavulanic acid with Chloramphenicol?
MediHelp rates the interaction as moderate. Amoxicillin-clavulanic acid and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol is bacteriostatic and may reduce the bactericidal effect of amoxicillin in vitro. The clinical relevance is uncertain but could matter in severe infections.
How serious is the interaction between Amoxicillin-clavulanic acid and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining them in serious infections requiring bactericidal therapy and use a single appropriate agent where possible. If both are used, monitor clinical response.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Pretomanid. The full list is on the Amoxicillin-clavulanic acid page.
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