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Interações medicamentosas

Amphotericin b + Corticotropin

Gravidade: Moderada

Amphotericin b and Corticotropin: moderate interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

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Resumo

Both amphotericin B and corticotropin promote potassium loss. Together they can cause severe hypokalemia, which may lead to arrhythmias and muscle weakness, and may be worsened by cardiac glycosides.

O que esta interação significa em palavras simples

Amphotericin b and Corticotropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Amphotericin b belongs to Anti Fungals; Corticotropin belongs to Endocrine.

Nível de evidência: Moderate

Por que acontece

Additive renal potassium wasting (amphotericin tubular effect plus mineralocorticoid effect of corticotropin).

O que fazer

Monitor serum potassium and cardiac status, and supplement potassium as needed. Check magnesium too.

O que perguntar ao farmacêutico

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Amphotericin b with Corticotropin?

MediHelp rates the interaction as moderate. Amphotericin b and Corticotropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both amphotericin B and corticotropin promote potassium loss. Together they can cause severe hypokalemia, which may lead to arrhythmias and muscle weakness, and may be worsened by cardiac glycosides.

How serious is the interaction between Amphotericin b and Corticotropin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and cardiac status, and supplement potassium as needed. Check magnesium too.

What other medicines interact with Amphotericin b?

MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.

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