Interações medicamentosas
Amphotericin b deoxycholate + Digoxin
Gravidade: Grave
Amphotericin b deoxycholate and Digoxin: major interaction.
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Resumo
Amphotericin B commonly causes hypokalemia and hypomagnesemia, which sensitize the myocardium to digoxin. This increases the risk of digoxin toxicity and arrhythmias even at normal serum levels.
O que esta interação significa em palavras simples
Amphotericin b deoxycholate and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Amphotericin-induced renal potassium and magnesium wasting produces additive pharmacodynamic enhancement of digoxin toxicity.
O que fazer
Monitor and correct serum potassium and magnesium regularly. Check digoxin levels and ECG, and consider a digoxin dose reduction if electrolyte disturbances persist.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Digoxin
- Digoxin + Lily of the valley Contraindicada
- Digoxin + Squill Contraindicada
- Adagrasib + Digoxin Grave
- Amiodarone + Digoxin Grave
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Grave
- Amphotericin b + Digoxin Grave
Perguntas frequentes
Can I take Amphotericin b deoxycholate with Digoxin?
MediHelp rates the interaction as major. Amphotericin b deoxycholate and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amphotericin B commonly causes hypokalemia and hypomagnesemia, which sensitize the myocardium to digoxin. This increases the risk of digoxin toxicity and arrhythmias even at normal serum levels.
How serious is the interaction between Amphotericin b deoxycholate and Digoxin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor and correct serum potassium and magnesium regularly. Check digoxin levels and ECG, and consider a digoxin dose reduction if electrolyte disturbances persist.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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