Interações medicamentosas
Amlodipine-hydrochlorothiazide-valsartan + Digoxin
Gravidade: Grave
Amlodipine-hydrochlorothiazide-valsartan and Digoxin: major interaction.
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Resumo
Hydrochlorothiazide-induced hypokalemia and hypomagnesemia increase myocardial sensitivity to digoxin and the risk of arrhythmias. Valsartan-related renal changes may also modestly raise digoxin levels.
O que esta interação significa em palavras simples
Amlodipine-hydrochlorothiazide-valsartan and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Digoxin belongs to Cardiovascular.
Por que acontece
Diuretic-induced hypokalemia and hypomagnesemia enhance digoxin toxicity, with possible reduced renal digoxin clearance.
O que fazer
Monitor potassium, magnesium and renal function regularly and keep potassium in the normal range. Check digoxin levels and watch for toxicity symptoms.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicada
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicada
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicada
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Grave
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Grave
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Grave
Outras interações de Digoxin
- Digoxin + Lily of the valley Contraindicada
- Digoxin + Squill Contraindicada
- Adagrasib + Digoxin Grave
- Amiodarone + Digoxin Grave
- Amphotericin b deoxycholate + Digoxin Grave
- Amphotericin b + Digoxin Grave
Perguntas frequentes
Can I take Amlodipine-hydrochlorothiazide-valsartan with Digoxin?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Hydrochlorothiazide-induced hypokalemia and hypomagnesemia increase myocardial sensitivity to digoxin and the risk of arrhythmias. Valsartan-related renal changes may also modestly raise digoxin levels.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Digoxin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium, magnesium and renal function regularly and keep potassium in the normal range. Check digoxin levels and watch for toxicity symptoms.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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