Interações medicamentosas
Amiodarone + Digoxin
Gravidade: Grave
Amiodarone and Digoxin: major interaction.
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Amiodarone increases serum digoxin concentrations, often substantially, and may lead to digoxin toxicity. Additive effects on sinus and AV nodal function raise the risk of bradycardia and heart block. The interaction develops over days to weeks and can persist because of amiodarone's long half-life.
O que esta interação significa em palavras simples
Amiodarone and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Digoxin belongs to Cardiovascular.
Por que acontece
Amiodarone inhibits P-glycoprotein and reduces renal and non-renal digoxin clearance, with additive pharmacodynamic effects on cardiac conduction.
O que fazer
Reduce the digoxin dose by roughly one-third to one-half when starting amiodarone, or consider stopping digoxin if no longer necessary. Measure serum digoxin levels and review after one to two weeks, and monitor heart rate and ECG.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Amiodarone e Digoxin, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Referências
Outras interações de Digoxin
- Digoxin + Lily of the valley Contraindicada
- Digoxin + Squill Contraindicada
- Adagrasib + Digoxin Grave
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Grave
- Amphotericin b deoxycholate + Digoxin Grave
- Amphotericin b + Digoxin Grave
Outras interações de Amiodarone
- Amiodarone + Amisulpride Contraindicada
- Amiodarone + Arsenic trioxide Contraindicada
- Amiodarone + Dofetilide Contraindicada
- Amiodarone + Dronedarone Contraindicada
- Amiodarone + Droperidol Contraindicada
- Amiodarone + Eliglustat Contraindicada
Perguntas frequentes
Can I take Amiodarone with Digoxin?
MediHelp rates the interaction as major. Amiodarone and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone increases serum digoxin concentrations, often substantially, and may lead to digoxin toxicity. Additive effects on sinus and AV nodal function raise the risk of bradycardia and heart block. The interaction develops over days to weeks and can persist because of amiodarone's long half-life.
How serious is the interaction between Amiodarone and Digoxin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the digoxin dose by roughly one-third to one-half when starting amiodarone, or consider stopping digoxin if no longer necessary. Measure serum digoxin levels and review after one to two weeks, and monitor heart rate and ECG.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
