Interações medicamentosas
Antithymocyte globulin equine + Tofacitinib
Gravidade: Grave
Antithymocyte globulin equine and Tofacitinib: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Tofacitinib combined with a potent T-cell depleting agent greatly increases the risk of serious and opportunistic infection. Labeling advises against use with potent immunosuppressants.
O que esta interação significa em palavras simples
Antithymocyte globulin equine and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive immunosuppression from JAK inhibition and T-cell depletion.
O que fazer
Avoid combination where possible. If used, monitor closely for infection and lymphocyte counts.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Tofacitinib
- Baricitinib + Tofacitinib Contraindicada
- Cladribine + Tofacitinib Contraindicada
- Tofacitinib + Upadacitinib Contraindicada
- Abatacept + Tofacitinib Grave
- Anti-thymocyte + Tofacitinib Grave
- Antithymocyte globulin rabbit + Tofacitinib Grave
Perguntas frequentes
Can I take Antithymocyte globulin equine with Tofacitinib?
MediHelp rates the interaction as major. Antithymocyte globulin equine and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tofacitinib combined with a potent T-cell depleting agent greatly increases the risk of serious and opportunistic infection. Labeling advises against use with potent immunosuppressants.
How serious is the interaction between Antithymocyte globulin equine and Tofacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination where possible. If used, monitor closely for infection and lymphocyte counts.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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