Interações medicamentosas
Tofacitinib + Upadacitinib
Gravidade: Contraindicada
Tofacitinib and Upadacitinib: contraindicated interaction.
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Resumo
Two JAK inhibitors together duplicate pharmacology and give additive immunosuppression, increasing the risk of serious infection, cytopenias and other class adverse effects. There is no evidence of benefit from combining them.
O que esta interação significa em palavras simples
Tofacitinib and Upadacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Tofacitinib belongs to Musculoskeletal; Upadacitinib belongs to Musculoskeletal.
Por que acontece
Duplicate JAK inhibition leads to additive immunosuppression.
O que fazer
Do not use together; use one JAK inhibitor only, and stop the first before starting the other.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Tofacitinib
- Baricitinib + Tofacitinib Contraindicada
- Cladribine + Tofacitinib Contraindicada
- Abatacept + Tofacitinib Grave
- Anti-thymocyte + Tofacitinib Grave
- Antithymocyte globulin equine + Tofacitinib Grave
- Antithymocyte globulin rabbit + Tofacitinib Grave
Outras interações de Upadacitinib
- Abrocitinib + Upadacitinib Contraindicada
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicada
- Baricitinib + Upadacitinib Contraindicada
- Bcg vaccine live + Upadacitinib Contraindicada
- Cyclosporine + Upadacitinib Contraindicada
- Dengue vaccine + Upadacitinib Contraindicada
Perguntas frequentes
Can I take Tofacitinib with Upadacitinib?
MediHelp rates the interaction as contraindicated. Tofacitinib and Upadacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Two JAK inhibitors together duplicate pharmacology and give additive immunosuppression, increasing the risk of serious infection, cytopenias and other class adverse effects. There is no evidence of benefit from combining them.
How serious is the interaction between Tofacitinib and Upadacitinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; use one JAK inhibitor only, and stop the first before starting the other.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Abatacept. The full list is on the Tofacitinib page.
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