Interações medicamentosas
Anti-thymocyte + Tofacitinib
Gravidade: Grave
Anti-thymocyte and Tofacitinib: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Tofacitinib is a Janus kinase inhibitor that impairs cytokine signalling, and anti-thymocyte globulin depletes T cells. Combined use markedly increases the risk of serious opportunistic and other infections.
O que esta interação significa em palavras simples
Anti-thymocyte and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anti-thymocyte belongs to Miscellaneous; Tofacitinib belongs to Musculoskeletal.
Por que acontece
Additive immunosuppression through T-cell depletion and JAK inhibition.
O que fazer
Avoid combining where possible; the label advises against use of tofacitinib with potent immunosuppressants. If combined, monitor closely for infection and use appropriate prophylaxis.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Anti-thymocyte
- Anti-thymocyte + Bcg vaccine live Contraindicada
- Anti-thymocyte + Influenza virus vaccine quadrivalent intranasal Contraindicada
- Anti-thymocyte + Measles mumps and rubella vaccine live Contraindicada
- Anti-thymocyte + Measles mumps rubella and varicella vaccine live Contraindicada
- Anti-thymocyte + Measles vaccine Contraindicada
- Anti-thymocyte + Rotavirus oral vaccine live Contraindicada
Outras interações de Tofacitinib
- Baricitinib + Tofacitinib Contraindicada
- Cladribine + Tofacitinib Contraindicada
- Tofacitinib + Upadacitinib Contraindicada
- Abatacept + Tofacitinib Grave
- Antithymocyte globulin equine + Tofacitinib Grave
- Antithymocyte globulin rabbit + Tofacitinib Grave
Perguntas frequentes
Can I take Anti-thymocyte with Tofacitinib?
MediHelp rates the interaction as major. Anti-thymocyte and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tofacitinib is a Janus kinase inhibitor that impairs cytokine signalling, and anti-thymocyte globulin depletes T cells. Combined use markedly increases the risk of serious opportunistic and other infections.
How serious is the interaction between Anti-thymocyte and Tofacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; the label advises against use of tofacitinib with potent immunosuppressants. If combined, monitor closely for infection and use appropriate prophylaxis.
What other medicines interact with Anti-thymocyte?
MediHelp also lists interactions of Anti-thymocyte with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Anti-thymocyte page.
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