Interações medicamentosas
Defibrotide + Edoxaban
Gravidade: Contraindicada
Defibrotide and Edoxaban: contraindicated interaction.
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Resumo
Defibrotide has profibrinolytic and antithrombotic activity and may add to the bleeding risk of anticoagulants such as edoxaban. Defibrotide labeling contraindicates concomitant systemic anticoagulants or fibrinolytics. Serious hemorrhage is the concern.
O que esta interação significa em palavras simples
Defibrotide and Edoxaban are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Defibrotide belongs to Cardiovascular; Edoxaban belongs to Cardiovascular.
Por que acontece
Additive pharmacodynamic effects on hemostasis from factor Xa inhibition and defibrotide's profibrinolytic activity.
O que fazer
Do not co-administer; hold edoxaban while defibrotide is being given. Resume anticoagulation only after defibrotide therapy is finished and bleeding risk has been reassessed.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Edoxaban
- Apixaban + Edoxaban Contraindicada
- Edoxaban + Ketorolac Contraindicada
- Abciximab + Edoxaban Grave
- Acetylsalicylic acid + Edoxaban Grave
- Argatroban + Edoxaban Grave
- Aspirin rectal + Edoxaban Grave
Outras interações de Defibrotide
- Alteplase + Defibrotide Contraindicada
- Apixaban + Defibrotide Contraindicada
- Argatroban + Defibrotide Contraindicada
- Dabigatran etexilate + Defibrotide Contraindicada
- Dalteparin + Defibrotide Contraindicada
- Defibrotide + Enoxaparin Contraindicada
Perguntas frequentes
Can I take Defibrotide with Edoxaban?
MediHelp rates the interaction as contraindicated. Defibrotide and Edoxaban are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Defibrotide has profibrinolytic and antithrombotic activity and may add to the bleeding risk of anticoagulants such as edoxaban. Defibrotide labeling contraindicates concomitant systemic anticoagulants or fibrinolytics. Serious hemorrhage is the concern.
How serious is the interaction between Defibrotide and Edoxaban?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; hold edoxaban while defibrotide is being given. Resume anticoagulation only after defibrotide therapy is finished and bleeding risk has been reassessed.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Ketorolac, Abciximab. The full list is on the Edoxaban page.
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