Interações medicamentosas
Apixaban + Eptifibatide
Gravidade: Grave
Apixaban and Eptifibatide: major interaction.
Última atualização
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Resumo
Eptifibatide blocks platelet glycoprotein IIb/IIIa receptors and, with apixaban, substantially increases the risk of serious bleeding. It is used in acute coronary settings where anticoagulation overlap may occur.
O que esta interação significa em palavras simples
Apixaban and Eptifibatide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apixaban belongs to Cardiovascular; Eptifibatide belongs to Cardiovascular.
Por que acontece
Additive hemostatic impairment from platelet aggregation blockade and factor Xa inhibition.
O que fazer
Avoid unless clearly necessary; if combined, monitor closely for bleeding and check hemoglobin and renal function. Consider holding apixaban during the infusion per the treating cardiology team.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Apixaban
- Apixaban + Dabigatran Contraindicada
- Apixaban + Defibrotide Contraindicada
- Apixaban + Edoxaban Contraindicada
- Apixaban + Ketorolac Contraindicada
- Apixaban + Mifepristone Contraindicada
- Abciximab + Apixaban Grave
Outras interações de Eptifibatide
Perguntas frequentes
Can I take Apixaban with Eptifibatide?
MediHelp rates the interaction as major. Apixaban and Eptifibatide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eptifibatide blocks platelet glycoprotein IIb/IIIa receptors and, with apixaban, substantially increases the risk of serious bleeding. It is used in acute coronary settings where anticoagulation overlap may occur.
How serious is the interaction between Apixaban and Eptifibatide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless clearly necessary; if combined, monitor closely for bleeding and check hemoglobin and renal function. Consider holding apixaban during the infusion per the treating cardiology team.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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