Interações medicamentosas
Cobimetinib + Netupitant-palonosetron
Gravidade: Grave
Cobimetinib and Netupitant-palonosetron: major interaction.
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Resumo
Netupitant inhibits CYP3A4 and can increase cobimetinib exposure. This may increase toxicities such as hemorrhage, rhabdomyolysis, retinopathy and liver injury.
O que esta interação significa em palavras simples
Cobimetinib and Netupitant-palonosetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cobimetinib belongs to Oncology; Netupitant-palonosetron belongs to Gastrointestinal Tract.
Por que acontece
CYP3A4 inhibition by netupitant reduces cobimetinib clearance.
O que fazer
Prefer an antiemetic that does not inhibit CYP3A4. If short-term use is unavoidable, reduce cobimetinib to the labeled dose for moderate inhibitors and monitor for toxicity.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Netupitant-palonosetron
Outras interações de Cobimetinib
- Cobimetinib + Efavirenz Contraindicada
- Cobimetinib + Posaconazole Contraindicada
- Amobarbital + Cobimetinib Grave
- Apalutamide + Cobimetinib Grave
- Aprepitant + Cobimetinib Grave
- Bosentan + Cobimetinib Grave
Perguntas frequentes
Can I take Cobimetinib with Netupitant-palonosetron?
MediHelp rates the interaction as major. Cobimetinib and Netupitant-palonosetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Netupitant inhibits CYP3A4 and can increase cobimetinib exposure. This may increase toxicities such as hemorrhage, rhabdomyolysis, retinopathy and liver injury.
How serious is the interaction between Cobimetinib and Netupitant-palonosetron?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antiemetic that does not inhibit CYP3A4. If short-term use is unavoidable, reduce cobimetinib to the labeled dose for moderate inhibitors and monitor for toxicity.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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