Interações medicamentosas
Apraclonidine + Tranylcypromine
Gravidade: Grave
Apraclonidine and Tranylcypromine: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Apraclonidine is an alpha-2 agonist eye drop with limited systemic exposure, but labeling contraindicates its use with MAOIs. MAOIs may alter catecholamine handling and unpredictably change blood pressure responses.
O que esta interação significa em palavras simples
Apraclonidine and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apraclonidine belongs to Cardiovascular; Tranylcypromine belongs to Central Nervous System.
Por que acontece
The mechanism is not well established; MAOI-related changes in catecholamine metabolism may alter responses to alpha-agonists.
O que fazer
Avoid apraclonidine in patients on tranylcypromine and select another ocular hypotensive agent such as a prostaglandin analogue or beta-blocker as appropriate. If it is unavoidable, monitor blood pressure and heart rate.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Apraclonidine e Tranylcypromine, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicada
- Amitriptyline + Tranylcypromine Contraindicada
- Amoxapine + Tranylcypromine Contraindicada
- Atomoxetine + Tranylcypromine Contraindicada
- Benzphetamine + Tranylcypromine Contraindicada
- Brimonidine + Tranylcypromine Contraindicada
Outras interações de Apraclonidine
- Apraclonidine + Isocarboxazid Contraindicada
- Apraclonidine + Linezolid Grave
- Apraclonidine + Phenelzine Grave
- Apraclonidine + Rasagiline Grave
- Apraclonidine + Selegiline Grave
Perguntas frequentes
Can I take Apraclonidine with Tranylcypromine?
MediHelp rates the interaction as major. Apraclonidine and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apraclonidine is an alpha-2 agonist eye drop with limited systemic exposure, but labeling contraindicates its use with MAOIs. MAOIs may alter catecholamine handling and unpredictably change blood pressure responses.
How serious is the interaction between Apraclonidine and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid apraclonidine in patients on tranylcypromine and select another ocular hypotensive agent such as a prostaglandin analogue or beta-blocker as appropriate. If it is unavoidable, monitor blood pressure and heart rate.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
