Drug interactions
Aripiprazole + Metoclopramide
Severity: Major
Aripiprazole and Metoclopramide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs block dopamine D2 receptors, so combined use increases the risk of extrapyramidal symptoms, tardive dyskinesia and rarely neuroleptic malignant syndrome. Aripiprazole is a partial agonist, but the risk remains.
What this interaction means in plain words
Aripiprazole and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aripiprazole belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive central dopamine D2 receptor antagonism.
What to do
Avoid combining where possible and choose an antiemetic without central dopamine antagonism, such as ondansetron. If unavoidable, use the shortest course and monitor for movement disorders and fever with rigidity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Metoclopramide
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Metoclopramide?
MediHelp rates the interaction as major. Aripiprazole and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs block dopamine D2 receptors, so combined use increases the risk of extrapyramidal symptoms, tardive dyskinesia and rarely neuroleptic malignant syndrome. Aripiprazole is a partial agonist, but the risk remains.
How serious is the interaction between Aripiprazole and Metoclopramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible and choose an antiemetic without central dopamine antagonism, such as ondansetron. If unavoidable, use the shortest course and monitor for movement disorders and fever with rigidity.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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