Interações medicamentosas
Aripiprazole + Oliceridine
Gravidade: Grave
Aripiprazole and Oliceridine: major interaction.
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Resumo
Oliceridine is an opioid that causes sedation and respiratory depression, and aripiprazole adds CNS depressant effects. Oliceridine is also partly metabolized by CYP3A4 and CYP2D6, which aripiprazole does not substantially affect, so the main concern is additive depression.
O que esta interação significa em palavras simples
Aripiprazole and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aripiprazole belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Por que acontece
Additive CNS and respiratory depression between an opioid and an antipsychotic.
O que fazer
Reserve combined use for patients without adequate alternatives, using the lowest oliceridine dose for the shortest duration. Monitor sedation and respiratory rate closely.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Aripiprazole
- Aripiprazole + Pimozide Contraindicada
- Aripiprazole + Thioridazine Contraindicada
- Amisulpride + Aripiprazole Grave
- Aripiprazole + Arsenic trioxide Grave
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Grave
- Aripiprazole + Carbamazepine Grave
Outras interações de Oliceridine
- Isocarboxazid + Oliceridine Contraindicada
- Alprazolam + Oliceridine Grave
- Amiodarone + Oliceridine Grave
- Amisulpride + Oliceridine Grave
- Amitriptyline + Oliceridine Grave
- Amobarbital + Oliceridine Grave
Perguntas frequentes
Can I take Aripiprazole with Oliceridine?
MediHelp rates the interaction as major. Aripiprazole and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oliceridine is an opioid that causes sedation and respiratory depression, and aripiprazole adds CNS depressant effects. Oliceridine is also partly metabolized by CYP3A4 and CYP2D6, which aripiprazole does not substantially affect, so the main concern is additive depression.
How serious is the interaction between Aripiprazole and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve combined use for patients without adequate alternatives, using the lowest oliceridine dose for the shortest duration. Monitor sedation and respiratory rate closely.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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