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Interações medicamentosas

Arsenic trioxide + Quinidine

Gravidade: Contraindicada

Arsenic trioxide and Quinidine: contraindicated interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

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Resumo

Both drugs prolong the QT interval, and arsenic trioxide is also linked to torsades de pointes and complete AV block. Combined use raises the risk of life-threatening ventricular arrhythmia.

O que esta interação significa em palavras simples

Arsenic trioxide and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Arsenic trioxide belongs to Oncology; Quinidine belongs to Anti Parasitic.

Nível de evidência: Moderate

Por que acontece

Additive blockade of cardiac repolarizing potassium currents causing QT prolongation.

O que fazer

Avoid the combination and choose a non-QT-prolonging antiarrhythmic. If unavoidable, correct potassium and magnesium and monitor ECG closely.

O que perguntar ao farmacêutico

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Arsenic trioxide with Quinidine?

MediHelp rates the interaction as contraindicated. Arsenic trioxide and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and arsenic trioxide is also linked to torsades de pointes and complete AV block. Combined use raises the risk of life-threatening ventricular arrhythmia.

How serious is the interaction between Arsenic trioxide and Quinidine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-QT-prolonging antiarrhythmic. If unavoidable, correct potassium and magnesium and monitor ECG closely.

What other medicines interact with Quinidine?

MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Artemether / lumefantrine, Chloroquine. The full list is on the Quinidine page.

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