Interações medicamentosas
Asenapine + Pefloxacin
Gravidade: Moderada
Asenapine and Pefloxacin: moderate interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Pefloxacin inhibits CYP1A2, the main enzyme metabolizing asenapine, so asenapine exposure may increase. Higher levels could add to sedation, hypotension and QT prolongation, and pefloxacin itself can prolong the QT interval.
O que esta interação significa em palavras simples
Asenapine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Pefloxacin belongs to Anti Bacterial.
Por que acontece
Inhibition of CYP1A2-mediated asenapine metabolism, with possible additive QT prolongation.
O que fazer
Monitor for sedation, hypotension and QT-related symptoms, and consider an ECG in patients with cardiac risk factors. Choose an antibiotic that does not inhibit CYP1A2 or prolong QT if possible.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Asenapine e Pefloxacin, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Asenapine
- Asenapine + Pimozide Contraindicada
- Asenapine + Thioridazine Contraindicada
- Asenapine + Vandetanib Contraindicada
- Adagrasib + Asenapine Grave
- Alfentanil + Asenapine Grave
- Alfuzosin + Asenapine Grave
Outras interações de Pefloxacin
- Pefloxacin + Tizanidine Contraindicada
- Clozapine + Pefloxacin Grave
- Duloxetine + Pefloxacin Grave
- Pefloxacin + Theophylline Grave
- Caffeine + Pefloxacin Moderada
- Cimetidine + Pefloxacin Moderada
Perguntas frequentes
Can I take Asenapine with Pefloxacin?
MediHelp rates the interaction as moderate. Asenapine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pefloxacin inhibits CYP1A2, the main enzyme metabolizing asenapine, so asenapine exposure may increase. Higher levels could add to sedation, hypotension and QT prolongation, and pefloxacin itself can prolong the QT interval.
How serious is the interaction between Asenapine and Pefloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, hypotension and QT-related symptoms, and consider an ECG in patients with cardiac risk factors. Choose an antibiotic that does not inhibit CYP1A2 or prolong QT if possible.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
