Interações medicamentosas
Cimetidine + Pefloxacin
Gravidade: Moderada
Cimetidine and Pefloxacin: moderate interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Cimetidine has been reported to slow pefloxacin elimination, raising its levels and half-life. Increased fluoroquinolone adverse effects such as CNS effects are possible but this is rarely significant.
O que esta interação significa em palavras simples
Cimetidine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Pefloxacin belongs to Anti Bacterial.
Por que acontece
Cimetidine inhibits hepatic oxidative metabolism of pefloxacin, reducing its clearance.
O que fazer
Monitor for CNS effects and tendon or gastrointestinal adverse effects, and consider lowering the pefloxacin dose in hepatic impairment or the elderly.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cimetidine
- Cimetidine + Dofetilide Contraindicada
- Cimetidine + Fezolinetant Contraindicada
- Alfentanil + Cimetidine Grave
- Atazanavir + Cimetidine Grave
- Carmustine + Cimetidine Grave
- Cimetidine + Citalopram Grave
Outras interações de Pefloxacin
- Pefloxacin + Tizanidine Contraindicada
- Clozapine + Pefloxacin Grave
- Duloxetine + Pefloxacin Grave
- Pefloxacin + Theophylline Grave
- Asenapine + Pefloxacin Moderada
- Caffeine + Pefloxacin Moderada
Perguntas frequentes
Can I take Cimetidine with Pefloxacin?
MediHelp rates the interaction as moderate. Cimetidine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine has been reported to slow pefloxacin elimination, raising its levels and half-life. Increased fluoroquinolone adverse effects such as CNS effects are possible but this is rarely significant.
How serious is the interaction between Cimetidine and Pefloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for CNS effects and tendon or gastrointestinal adverse effects, and consider lowering the pefloxacin dose in hepatic impairment or the elderly.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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