Interações medicamentosas
Asenapine + Pheniramine
Gravidade: Moderada
Asenapine and Pheniramine: moderate interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Pheniramine is a sedating first-generation antihistamine and asenapine is also sedating, so combined use can produce marked drowsiness and impaired alertness. Anticholinergic effects of pheniramine may add to the effects of asenapine in susceptible patients.
O que esta interação significa em palavras simples
Asenapine and Pheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Pheniramine belongs to Respiratory.
Por que acontece
Additive CNS depression from H1 antagonism and antipsychotic receptor blockade.
O que fazer
Counsel patients about sedation and avoid driving or hazardous tasks. Prefer a non-sedating antihistamine if one is needed regularly.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Para assinantes do Pro+
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Outras interações de Asenapine
- Asenapine + Pimozide Contraindicada
- Asenapine + Thioridazine Contraindicada
- Asenapine + Vandetanib Contraindicada
- Adagrasib + Asenapine Grave
- Alfentanil + Asenapine Grave
- Alfuzosin + Asenapine Grave
Outras interações de Pheniramine
- Amisulpride + Pheniramine Moderada
- Brexpiprazole + Pheniramine Moderada
- Brivaracetam + Pheniramine Moderada
- Cariprazine + Pheniramine Moderada
- Fentanyl + Pheniramine Moderada
- Levetiracetam + Pheniramine Moderada
Perguntas frequentes
Can I take Asenapine with Pheniramine?
MediHelp rates the interaction as moderate. Asenapine and Pheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pheniramine is a sedating first-generation antihistamine and asenapine is also sedating, so combined use can produce marked drowsiness and impaired alertness. Anticholinergic effects of pheniramine may add to the effects of asenapine in susceptible patients.
How serious is the interaction between Asenapine and Pheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about sedation and avoid driving or hazardous tasks. Prefer a non-sedating antihistamine if one is needed regularly.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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