Interações medicamentosas
Brexpiprazole + Pheniramine
Gravidade: Moderada
Brexpiprazole and Pheniramine: moderate interaction.
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Resumo
Pheniramine is a sedating first-generation antihistamine, and brexpiprazole is also sedating. Together they may cause pronounced drowsiness and impaired psychomotor performance, and anticholinergic effects may be additive.
O que esta interação significa em palavras simples
Brexpiprazole and Pheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Pheniramine belongs to Respiratory.
Por que acontece
Additive CNS depression through histamine H1 receptor antagonism and other receptor blockade.
O que fazer
Counsel patients about drowsiness and avoiding driving or hazardous tasks. Prefer a non-sedating antihistamine if one is suitable.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Brexpiprazole
Outras interações de Pheniramine
- Amisulpride + Pheniramine Moderada
- Asenapine + Pheniramine Moderada
- Brivaracetam + Pheniramine Moderada
- Cariprazine + Pheniramine Moderada
- Fentanyl + Pheniramine Moderada
- Levetiracetam + Pheniramine Moderada
Perguntas frequentes
Can I take Brexpiprazole with Pheniramine?
MediHelp rates the interaction as moderate. Brexpiprazole and Pheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pheniramine is a sedating first-generation antihistamine, and brexpiprazole is also sedating. Together they may cause pronounced drowsiness and impaired psychomotor performance, and anticholinergic effects may be additive.
How serious is the interaction between Brexpiprazole and Pheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and avoiding driving or hazardous tasks. Prefer a non-sedating antihistamine if one is suitable.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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