Interações medicamentosas
Atazanavir + Pantoprazole
Gravidade: Grave
Atazanavir and Pantoprazole: major interaction.
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Resumo
Atazanavir needs an acidic environment for dissolution, and pantoprazole markedly reduces its absorption. This can lead to subtherapeutic antiretroviral levels, virologic failure and resistance.
O que esta interação significa em palavras simples
Atazanavir and Pantoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Pantoprazole belongs to Gastrointestinal Tract.
Por que acontece
Elevated gastric pH reduces atazanavir solubility and oral absorption.
O que fazer
Avoid in treatment-experienced patients; in treatment-naive patients follow labeling with ritonavir boosting, limited PPI dose and staggered timing, with virologic monitoring.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Pantoprazole
- Pantoprazole + Rilpivirine Contraindicada
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- Dacomitinib + Pantoprazole Grave
- Dasatinib + Pantoprazole Grave
- Erlotinib + Pantoprazole Grave
- Gefitinib + Pantoprazole Grave
Outras interações de Atazanavir
- Alfuzosin + Atazanavir Contraindicada
- Atazanavir + Avanafil Contraindicada
- Atazanavir + Dronedarone Contraindicada
- Atazanavir + Eletriptan Contraindicada
- Atazanavir + Eplerenone Contraindicada
- Atazanavir + Ergotamine Contraindicada
Perguntas frequentes
Can I take Atazanavir with Pantoprazole?
MediHelp rates the interaction as major. Atazanavir and Pantoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir needs an acidic environment for dissolution, and pantoprazole markedly reduces its absorption. This can lead to subtherapeutic antiretroviral levels, virologic failure and resistance.
How serious is the interaction between Atazanavir and Pantoprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in treatment-experienced patients; in treatment-naive patients follow labeling with ritonavir boosting, limited PPI dose and staggered timing, with virologic monitoring.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Dacomitinib. The full list is on the Pantoprazole page.
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