Interações medicamentosas
Pantoprazole + Rilpivirine
Gravidade: Contraindicada
Pantoprazole and Rilpivirine: contraindicated interaction.
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Resumo
Oral rilpivirine requires acidic gastric conditions for absorption, and pantoprazole markedly reduces its exposure. This can cause virologic failure and NNRTI resistance, and labeling contraindicates PPIs with oral rilpivirine.
O que esta interação significa em palavras simples
Pantoprazole and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pantoprazole belongs to Gastrointestinal Tract; Rilpivirine belongs to Anti Virals.
Por que acontece
Increased gastric pH from proton pump inhibition reduces rilpivirine dissolution and absorption.
O que fazer
Do not use together. Choose a different acid suppressant, such as an H2 blocker with timed separation, or an alternative antiretroviral.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Pantoprazole
Outras interações de Rilpivirine
- Carbamazepine + Rilpivirine Contraindicada
- Dexamethasone + Rilpivirine Contraindicada
- Dexlansoprazole + Rilpivirine Contraindicada
- Efavirenz + Rilpivirine Contraindicada
- Eslicarbazepine + Rilpivirine Contraindicada
- Esomeprazole + Rilpivirine Contraindicada
Perguntas frequentes
Can I take Pantoprazole with Rilpivirine?
MediHelp rates the interaction as contraindicated. Pantoprazole and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oral rilpivirine requires acidic gastric conditions for absorption, and pantoprazole markedly reduces its exposure. This can cause virologic failure and NNRTI resistance, and labeling contraindicates PPIs with oral rilpivirine.
How serious is the interaction between Pantoprazole and Rilpivirine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Choose a different acid suppressant, such as an H2 blocker with timed separation, or an alternative antiretroviral.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Acalabrutinib, Atazanavir, Dacomitinib. The full list is on the Pantoprazole page.
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