Interações medicamentosas
Dacomitinib + Pantoprazole
Gravidade: Grave
Dacomitinib and Pantoprazole: major interaction.
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Resumo
Proton pump inhibitors reduce dacomitinib exposure, which may lessen its antitumor efficacy. The effect stems from reduced absorption at higher gastric pH.
O que esta interação significa em palavras simples
Dacomitinib and Pantoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dacomitinib belongs to Oncology; Pantoprazole belongs to Gastrointestinal Tract.
Por que acontece
Higher gastric pH from the proton pump inhibitor reduces dacomitinib solubility and absorption.
O que fazer
Avoid pantoprazole; if acid suppression is needed, use a locally acting antacid or an H2 blocker with dacomitinib given at least 6 hours before or 10 hours after.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Pantoprazole
- Pantoprazole + Rilpivirine Contraindicada
- Acalabrutinib + Pantoprazole Grave
- Atazanavir + Pantoprazole Grave
- Dasatinib + Pantoprazole Grave
- Erlotinib + Pantoprazole Grave
- Gefitinib + Pantoprazole Grave
Outras interações de Dacomitinib
- Dacomitinib + Thioridazine Contraindicada
- Amitriptyline + Dacomitinib Grave
- Atomoxetine + Dacomitinib Grave
- Brexpiprazole + Dacomitinib Grave
- Clomipramine + Dacomitinib Grave
- Dacomitinib + Desipramine Grave
Perguntas frequentes
Can I take Dacomitinib with Pantoprazole?
MediHelp rates the interaction as major. Dacomitinib and Pantoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Proton pump inhibitors reduce dacomitinib exposure, which may lessen its antitumor efficacy. The effect stems from reduced absorption at higher gastric pH.
How serious is the interaction between Dacomitinib and Pantoprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid pantoprazole; if acid suppression is needed, use a locally acting antacid or an H2 blocker with dacomitinib given at least 6 hours before or 10 hours after.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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