Interações medicamentosas
Azacitidine + Fingolimod
Gravidade: Grave
Azacitidine and Fingolimod: major interaction.
Última atualização
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Resumo
Azacitidine causes myelosuppression and fingolimod lowers circulating lymphocytes by sequestering them in lymphoid tissue. Together they may increase the risk of serious infection.
O que esta interação significa em palavras simples
Azacitidine and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azacitidine belongs to Oncology; Fingolimod belongs to Central Nervous System.
Por que acontece
Additive immunosuppression: lymphocyte sequestration from fingolimod plus bone marrow suppression from azacitidine.
O que fazer
Avoid the combination where possible, or monitor blood counts and infection signs closely. Consider stopping fingolimod during cytotoxic therapy, remembering its immune effects persist for weeks after discontinuation.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicada
- Bcg vaccine live + Fingolimod Contraindicada
- Fingolimod + Pimozide Contraindicada
- Fingolimod + Ponesimod Contraindicada
- Fingolimod + Quinidine Contraindicada
- Fingolimod + Siponimod Contraindicada
Outras interações de Azacitidine
- Azacitidine + Siponimod Grave
- Azacitidine + Denosumab Moderada
- Azacitidine + Dichlorphenamide Moderada
- Azacitidine + Hydroxyurea Moderada
- Azacitidine + Trastuzumab Moderada
Perguntas frequentes
Can I take Azacitidine with Fingolimod?
MediHelp rates the interaction as major. Azacitidine and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Azacitidine causes myelosuppression and fingolimod lowers circulating lymphocytes by sequestering them in lymphoid tissue. Together they may increase the risk of serious infection.
How serious is the interaction between Azacitidine and Fingolimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or monitor blood counts and infection signs closely. Consider stopping fingolimod during cytotoxic therapy, remembering its immune effects persist for weeks after discontinuation.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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