Interações medicamentosas
Azacitidine + Hydroxyurea
Gravidade: Moderada
Azacitidine and Hydroxyurea: moderate interaction.
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Resumo
Both agents suppress bone marrow function. Used together they can deepen neutropenia, anemia and thrombocytopenia, raising the risk of infection and bleeding.
O que esta interação significa em palavras simples
Azacitidine and Hydroxyurea can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azacitidine belongs to Oncology; Hydroxyurea belongs to Miscellaneous.
Por que acontece
Additive myelosuppression from two cytotoxic agents.
O que fazer
Monitor complete blood counts regularly and adjust doses or delay cycles for significant cytopenias. Provide supportive care as needed.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Hydroxyurea
Outras interações de Azacitidine
- Azacitidine + Fingolimod Grave
- Azacitidine + Siponimod Grave
- Azacitidine + Denosumab Moderada
- Azacitidine + Dichlorphenamide Moderada
- Azacitidine + Trastuzumab Moderada
Perguntas frequentes
Can I take Azacitidine with Hydroxyurea?
MediHelp rates the interaction as moderate. Azacitidine and Hydroxyurea can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents suppress bone marrow function. Used together they can deepen neutropenia, anemia and thrombocytopenia, raising the risk of infection and bleeding.
How serious is the interaction between Azacitidine and Hydroxyurea?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and adjust doses or delay cycles for significant cytopenias. Provide supportive care as needed.
What other medicines interact with Hydroxyurea?
MediHelp also lists interactions of Hydroxyurea with, for example, Didanosine, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel. The full list is on the Hydroxyurea page.
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