Interações medicamentosas
Azacitidine + Trastuzumab
Gravidade: Moderada
Azacitidine and Trastuzumab: moderate interaction.
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Resumo
Azacitidine is myelosuppressive, and trastuzumab has been associated with higher rates of neutropenia and febrile neutropenia when combined with myelosuppressive chemotherapy. The combination may increase infection risk.
O que esta interação significa em palavras simples
Azacitidine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azacitidine belongs to Oncology; Trastuzumab belongs to Oncology.
Por que acontece
Additive hematologic toxicity; trastuzumab may worsen chemotherapy-induced neutropenia by an incompletely understood mechanism.
O que fazer
Monitor complete blood counts regularly and watch for fever or infection; manage neutropenia per standard protocols.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Trastuzumab
Outras interações de Azacitidine
- Azacitidine + Fingolimod Grave
- Azacitidine + Siponimod Grave
- Azacitidine + Denosumab Moderada
- Azacitidine + Dichlorphenamide Moderada
- Azacitidine + Hydroxyurea Moderada
Perguntas frequentes
Can I take Azacitidine with Trastuzumab?
MediHelp rates the interaction as moderate. Azacitidine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azacitidine is myelosuppressive, and trastuzumab has been associated with higher rates of neutropenia and febrile neutropenia when combined with myelosuppressive chemotherapy. The combination may increase infection risk.
How serious is the interaction between Azacitidine and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and watch for fever or infection; manage neutropenia per standard protocols.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin liposomal, Doxorubicin. The full list is on the Trastuzumab page.
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