Interações medicamentosas
Azathioprine + Ublituximab
Gravidade: Grave
Azathioprine and Ublituximab: major interaction.
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Resumo
Ublituximab depletes B cells while azathioprine suppresses lymphocyte proliferation, so combined use may increase the risk of serious infections.
O que esta interação significa em palavras simples
Azathioprine and Ublituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azathioprine belongs to Gastrointestinal Tract; Ublituximab belongs to Miscellaneous.
Por que acontece
Additive immunosuppression from anti-CD20 B-cell depletion and azathioprine lymphocyte suppression.
O que fazer
Avoid combining where possible, or monitor closely for infection and check blood counts regularly. Consider the duration of effect of each drug when sequencing therapy.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicada
- Azathioprine + Bcg vaccine live Contraindicada
- Azathioprine + Febuxostat Contraindicada
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicada
- Azathioprine + Measles mumps and rubella vaccine Contraindicada
- Azathioprine + Measles mumps and rubella vaccine live Contraindicada
Outras interações de Ublituximab
Perguntas frequentes
Can I take Azathioprine with Ublituximab?
MediHelp rates the interaction as major. Azathioprine and Ublituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ublituximab depletes B cells while azathioprine suppresses lymphocyte proliferation, so combined use may increase the risk of serious infections.
How serious is the interaction between Azathioprine and Ublituximab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, or monitor closely for infection and check blood counts regularly. Consider the duration of effect of each drug when sequencing therapy.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
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