Interações medicamentosas
Mercaptopurine + Ublituximab
Gravidade: Grave
Mercaptopurine and Ublituximab: major interaction.
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Resumo
Ublituximab depletes B cells, and mercaptopurine adds myelosuppressive and immunosuppressive effects. Together they can increase the risk of serious infections.
O que esta interação significa em palavras simples
Mercaptopurine and Ublituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mercaptopurine belongs to Oncology; Ublituximab belongs to Miscellaneous.
Por que acontece
Additive immunosuppression from anti-CD20 B-cell depletion and purine antimetabolite lymphocyte and marrow suppression.
O que fazer
Avoid combining where possible, or monitor closely for infection and check blood counts regularly. Consider the duration of effect of each drug when planning sequential therapy.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Mercaptopurine
- Adenovirus types 4 and 7 live + Mercaptopurine Contraindicada
- Azathioprine + Mercaptopurine Contraindicada
- Bcg vaccine live + Mercaptopurine Contraindicada
- Febuxostat + Mercaptopurine Contraindicada
- Influenza virus vaccine quadrivalent intranasal + Mercaptopurine Contraindicada
- Mercaptopurine + Smallpox vaccine live Contraindicada
Outras interações de Ublituximab
Perguntas frequentes
Can I take Mercaptopurine with Ublituximab?
MediHelp rates the interaction as major. Mercaptopurine and Ublituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ublituximab depletes B cells, and mercaptopurine adds myelosuppressive and immunosuppressive effects. Together they can increase the risk of serious infections.
How serious is the interaction between Mercaptopurine and Ublituximab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, or monitor closely for infection and check blood counts regularly. Consider the duration of effect of each drug when planning sequential therapy.
What other medicines interact with Mercaptopurine?
MediHelp also lists interactions of Mercaptopurine with, for example, Adenovirus types 4 and 7 live, Azathioprine, Bcg vaccine live. The full list is on the Mercaptopurine page.
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