Interações medicamentosas
Azithromycin + Domperidone
Gravidade: Contraindicada
Azithromycin and Domperidone: contraindicated interaction.
Última atualização Fontes: US FDA label
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Resumo
Both drugs prolong the QT interval, and combined use increases the risk of torsades de pointes and sudden cardiac death. European labeling contraindicates domperidone with QT-prolonging drugs. Patients with cardiac disease, electrolyte disturbance or other QT risk factors are at greatest risk.
O que esta interação significa em palavras simples
Azithromycin and Domperidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Azithromycin belongs to Anti Bacterial; Domperidone belongs to Gastrointestinal Tract.
Por que acontece
Pharmacodynamic: additive QT prolongation through hERG potassium channel blockade. Azithromycin is only a weak CYP3A4 inhibitor, so any pharmacokinetic contribution is small.
O que fazer
Do not co-administer. Choose an antibiotic without QT effect, such as a beta-lactam where appropriate, or an antiemetic or prokinetic without QT risk.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Referências
- Domperidone Summary of Product Characteristics - Contraindications and Interactions — EMA SmPC
- Zithromax (azithromycin) Prescribing Information - QT Prolongation — FDA Label
Outras interações de Azithromycin
- Azithromycin + Cisapride Contraindicada
- Azithromycin + Dronedarone Contraindicada
- Azithromycin + Pimozide Contraindicada
- Azithromycin + Piperaquine Contraindicada
- Azithromycin + Thioridazine Contraindicada
- Adagrasib + Azithromycin Grave
Outras interações de Domperidone
- Domperidone + Erythromycin Contraindicada
- Dexlansoprazole + Domperidone Moderada
- Domperidone + Lansoprazole Moderada
- Domperidone + Pantoprazole Moderada
- Domperidone + Polyethylene Glycol 3350 Moderada
- Domperidone + Rabeprazole Moderada
Perguntas frequentes
Can I take Azithromycin with Domperidone?
MediHelp rates the interaction as contraindicated. Azithromycin and Domperidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and combined use increases the risk of torsades de pointes and sudden cardiac death. European labeling contraindicates domperidone with QT-prolonging drugs. Patients with cardiac disease, electrolyte disturbance or other QT risk factors are at greatest risk.
How serious is the interaction between Azithromycin and Domperidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Choose an antibiotic without QT effect, such as a beta-lactam where appropriate, or an antiemetic or prokinetic without QT risk.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Dronedarone, Pimozide. The full list is on the Azithromycin page.
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