Interações medicamentosas
Azithromycin + Thioridazine
Gravidade: Contraindicada
Azithromycin and Thioridazine: contraindicated interaction.
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Resumo
Thioridazine causes marked dose-related QT prolongation and is itself contraindicated with other QT-prolonging drugs. Adding azithromycin raises the risk of torsades de pointes and sudden cardiac death.
O que esta interação significa em palavras simples
Azithromycin and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Azithromycin belongs to Anti Bacterial; Thioridazine belongs to Central Nervous System.
Por que acontece
Additive QT prolongation through hERG potassium channel blockade.
O que fazer
Avoid the combination and choose a non-macrolide antibiotic with no QT effect. If unavoidable, use continuous ECG monitoring and keep electrolytes normal.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Azithromycin
- Azithromycin + Cisapride Contraindicada
- Azithromycin + Domperidone Contraindicada
- Azithromycin + Dronedarone Contraindicada
- Azithromycin + Pimozide Contraindicada
- Azithromycin + Piperaquine Contraindicada
- Adagrasib + Azithromycin Grave
Outras interações de Thioridazine
- Abiraterone + Thioridazine Contraindicada
- Adagrasib + Thioridazine Contraindicada
- Amiodarone + Thioridazine Contraindicada
- Amisulpride + Thioridazine Contraindicada
- Amitriptyline + Thioridazine Contraindicada
- Amoxapine + Thioridazine Contraindicada
Perguntas frequentes
Can I take Azithromycin with Thioridazine?
MediHelp rates the interaction as contraindicated. Azithromycin and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine causes marked dose-related QT prolongation and is itself contraindicated with other QT-prolonging drugs. Adding azithromycin raises the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Azithromycin and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-macrolide antibiotic with no QT effect. If unavoidable, use continuous ECG monitoring and keep electrolytes normal.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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