Interações medicamentosas
Dexamethasone-tobramycin + Pancuronium
Gravidade: Grave
Dexamethasone-tobramycin and Pancuronium: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Aminoglycosides such as tobramycin can potentiate non-depolarizing neuromuscular blockers, causing prolonged paralysis and respiratory depression. This is clinically relevant mainly with systemic tobramycin, not with topical or ophthalmic use.
O que esta interação significa em palavras simples
Dexamethasone-tobramycin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexamethasone-tobramycin belongs to Anti Bacterial; Pancuronium belongs to Musculoskeletal.
Por que acontece
Tobramycin reduces presynaptic acetylcholine release and has postsynaptic effects, adding to neuromuscular blockade.
O que fazer
If systemic tobramycin is used perioperatively, monitor neuromuscular function with train-of-four and be prepared for prolonged ventilatory support. Reduce the blocker dose as needed.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Dexamethasone-tobramycin e Pancuronium, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Outras interações de Dexamethasone-tobramycin
Outras interações de Pancuronium
Perguntas frequentes
Can I take Dexamethasone-tobramycin with Pancuronium?
MediHelp rates the interaction as major. Dexamethasone-tobramycin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aminoglycosides such as tobramycin can potentiate non-depolarizing neuromuscular blockers, causing prolonged paralysis and respiratory depression. This is clinically relevant mainly with systemic tobramycin, not with topical or ophthalmic use.
How serious is the interaction between Dexamethasone-tobramycin and Pancuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If systemic tobramycin is used perioperatively, monitor neuromuscular function with train-of-four and be prepared for prolonged ventilatory support. Reduce the blocker dose as needed.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
