Interações medicamentosas
Baricitinib + Penicillin g procaine-penicillin g
Gravidade: Moderada
Baricitinib and Penicillin g procaine-penicillin g: moderate interaction.
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Resumo
Penicillin G is eliminated by renal tubular secretion and can inhibit OAT3, the transporter involved in baricitinib clearance. This may raise baricitinib exposure, although the clinical effect is probably modest.
O que esta interação significa em palavras simples
Baricitinib and Penicillin g procaine-penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baricitinib belongs to Musculoskeletal; Penicillin g procaine-penicillin g belongs to Anti Bacterial.
Por que acontece
Inhibition of renal OAT3-mediated tubular secretion of baricitinib by penicillin G reduces its elimination.
O que fazer
Monitor for baricitinib adverse effects such as infection and cytopenias during penicillin courses. Dose reduction is generally not needed for short courses of penicillin.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Penicillin g procaine-penicillin g
- Amifampridine + Penicillin g procaine-penicillin g Moderada
- Cholera vaccine + Penicillin g procaine-penicillin g Moderada
- Microbiota + Penicillin g procaine-penicillin g Moderada
- Omadacycline + Penicillin g procaine-penicillin g Moderada
- Penicillin g procaine-penicillin g + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderada
- Penicillin g procaine-penicillin g + Vadadustat Moderada
Outras interações de Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicada
- Baricitinib + Bcg vaccine live Contraindicada
- Baricitinib + Tofacitinib Contraindicada
- Baricitinib + Upadacitinib Contraindicada
- Abatacept + Baricitinib Grave
- Adalimumab + Baricitinib Grave
Perguntas frequentes
Can I take Baricitinib with Penicillin g procaine-penicillin g?
MediHelp rates the interaction as moderate. Baricitinib and Penicillin g procaine-penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Penicillin G is eliminated by renal tubular secretion and can inhibit OAT3, the transporter involved in baricitinib clearance. This may raise baricitinib exposure, although the clinical effect is probably modest.
How serious is the interaction between Baricitinib and Penicillin g procaine-penicillin g?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for baricitinib adverse effects such as infection and cytopenias during penicillin courses. Dose reduction is generally not needed for short courses of penicillin.
What other medicines interact with Penicillin g procaine-penicillin g?
MediHelp also lists interactions of Penicillin g procaine-penicillin g with, for example, Amifampridine, Cholera vaccine, Microbiota. The full list is on the Penicillin g procaine-penicillin g page.
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