Interações medicamentosas
Bcg vaccine live + Cilastatin-imipenem
Gravidade: Moderada
Bcg vaccine live and Cilastatin-imipenem: moderate interaction.
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Resumo
Live BCG relies on viable bacteria to induce immunity, and antibacterial agents active against mycobacteria or related organisms may reduce vaccine viability. Imipenem has some activity against BCG strains, so the immune response could be blunted.
O que esta interação significa em palavras simples
Bcg vaccine live and Cilastatin-imipenem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Antibacterial activity may reduce the viability of the live attenuated organism.
O que fazer
Delay BCG vaccination until the antibiotic course is complete, where this is clinically feasible. Repeat vaccination or assess response if the vaccine was given during therapy.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cilastatin-imipenem
Perguntas frequentes
Can I take Bcg vaccine live with Cilastatin-imipenem?
MediHelp rates the interaction as moderate. Bcg vaccine live and Cilastatin-imipenem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Live BCG relies on viable bacteria to induce immunity, and antibacterial agents active against mycobacteria or related organisms may reduce vaccine viability. Imipenem has some activity against BCG strains, so the immune response could be blunted.
How serious is the interaction between Bcg vaccine live and Cilastatin-imipenem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Delay BCG vaccination until the antibiotic course is complete, where this is clinically feasible. Repeat vaccination or assess response if the vaccine was given during therapy.
What other medicines interact with Cilastatin-imipenem?
MediHelp also lists interactions of Cilastatin-imipenem with, for example, Divalproex, Ganciclovir, Valproic acid. The full list is on the Cilastatin-imipenem page.
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