Interações medicamentosas
Cilastatin-imipenem + Cyclosporine
Gravidade: Moderada
Cilastatin-imipenem and Cyclosporine: moderate interaction.
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Resumo
Both imipenem and cyclosporine can lower the seizure threshold and cause neurotoxicity, and reports describe tremor, confusion and seizures when they are combined. Changes in cyclosporine concentrations have also been reported, though inconsistently.
O que esta interação significa em palavras simples
Cilastatin-imipenem and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Additive neurotoxic and proconvulsant effects; any effect on cyclosporine levels is not well established.
O que fazer
Monitor for tremor, confusion and seizures, and check cyclosporine trough levels during and after imipenem therapy. Consider an alternative antibiotic if neurological symptoms develop.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cilastatin-imipenem
Perguntas frequentes
Can I take Cilastatin-imipenem with Cyclosporine?
MediHelp rates the interaction as moderate. Cilastatin-imipenem and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both imipenem and cyclosporine can lower the seizure threshold and cause neurotoxicity, and reports describe tremor, confusion and seizures when they are combined. Changes in cyclosporine concentrations have also been reported, though inconsistently.
How serious is the interaction between Cilastatin-imipenem and Cyclosporine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tremor, confusion and seizures, and check cyclosporine trough levels during and after imipenem therapy. Consider an alternative antibiotic if neurological symptoms develop.
What other medicines interact with Cilastatin-imipenem?
MediHelp also lists interactions of Cilastatin-imipenem with, for example, Divalproex, Ganciclovir, Valproic acid. The full list is on the Cilastatin-imipenem page.
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