Interações medicamentosas
Cholera vaccine + Cilastatin-imipenem
Gravidade: Moderada
Cholera vaccine and Cilastatin-imipenem: moderate interaction.
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Resumo
Live oral cholera vaccine depends on gut colonization by the attenuated strain. Imipenem is a broad-spectrum antibiotic that may eliminate the strain and reduce the vaccine response. This could leave the patient inadequately protected.
O que esta interação significa em palavras simples
Cholera vaccine and Cilastatin-imipenem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Antibacterial activity against the live attenuated vaccine strain reduces its replication and immunogenicity.
O que fazer
Avoid vaccination within 14 days after systemic antibiotics, per labeling. Postpone elective vaccination or revaccinate after the course ends.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cilastatin-imipenem
Perguntas frequentes
Can I take Cholera vaccine with Cilastatin-imipenem?
MediHelp rates the interaction as moderate. Cholera vaccine and Cilastatin-imipenem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Live oral cholera vaccine depends on gut colonization by the attenuated strain. Imipenem is a broad-spectrum antibiotic that may eliminate the strain and reduce the vaccine response. This could leave the patient inadequately protected.
How serious is the interaction between Cholera vaccine and Cilastatin-imipenem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid vaccination within 14 days after systemic antibiotics, per labeling. Postpone elective vaccination or revaccinate after the course ends.
What other medicines interact with Cilastatin-imipenem?
MediHelp also lists interactions of Cilastatin-imipenem with, for example, Divalproex, Ganciclovir, Valproic acid. The full list is on the Cilastatin-imipenem page.
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